Publications

Sampognaro PJ, Arya S, Knudsen GM, Gunderson EL, Sandoval-Perez A, Hodul M, Bowles K, Craik CS, Jacobson MP, Kao AW. Mutations in α-synuclein, TDP-43 and tau prolong protein half-life through diminished degradation by lysosomal proteases. Molecular Neurodegeneration, May 2023. doi: 10.1186/s13024-023-00621-8. PMID: 37131250.

Argouarch AR, Schultz N, Yang AC, Jang Y, Garcia K, Cosme CG, Corrales CI, Nana AL, Karydas AM, Spina S, Grinberg LT, Miller B, Wyss-Coray T, Abyzov A, Goodarzi H, Seeley WW, Kao AW. Postmortem Human Dura Mater Cells Exhibit Phenotypic, Transcriptomic and Genetic Abnormalities that Impact their Use for Disease Modeling. Stem Cell Rev Rep. 2022 Jul 9. doi: 10.1007/s12015-022-10416-x. Epub ahead of print. PMID: 35809166.

Alquezar C, Schoch KM, Geier EG, Ramos EM, Scrivo A, Li KH, Argouarch AR, Mlynarski EE, Dombroski B, DeTure M, Dickson DW, Yokoyama JS, Cuervo AM, Burlingame AL, Schellenberg GD, Miller TM, Miller BL, Kao AW. TSC1 loss increases risk for tauopathy by inducing tau acetylation and preventing tau clearance via chaperone-mediated autophagy. Sci Adv. 2021 Nov 5;7(45):eabg3897. doi: 10.1126/sciadv.abg3897. Epub 2021 Nov 5. PMID: 34739309.

Mohan S, Sampognaro PJ, Argouarch AR, Maynard JC, Welch M, Patwardhan A, Courtney EC, Zhang J, Mason A, Li KH, Huang EJ, Seeley WW, Miller BL, Burlingame A, Jacobson MP, Kao AW. Processing of progranulin into granulins involves multiple lysosomal proteases and is affected in frontotemporal lobar degeneration. Mol Neurodegener. 2021 Aug 3;16(1):51. doi: 10.1186/s13024-021-00472-1. PMID: 34344440; PMCID: PMC8330050.

Chin MY, Patwardhan AR, Ang KH, Wang AL, Alquezar C, Welch M, Nguyen PT, Grabe M, Molofsky AV, Arkin MR, Kao AW. Genetically Encoded, pH-Sensitive mTFP1 Biosensor for Probing Lysosomal pH. ACS Sens. 2021 Jun 25;6(6):2168-2180. doi: 10.1021/acssensors.0c02318. Epub 2021 Jun 8. PMID: 34102054; PMCID: PMC8240087.

Alquezar C, Arya S, Kao AW. Tau Post-translational Modifications: Dynamic Transformers of Tau Function, Degradation, and Aggregation. Front Neurol. 2021 Jan 7;11:595532. doi: 10.3389/fneur.2020.595532. PMID: 33488497; PMCID: PMC7817643.

Gururaj S, Sampognaro PJ, Argouarch AR and Kao AW (2020) Progranulin Adsorbs to Polypropylene Tubes and Disrupts Functional Assays: Implications for Research, Biomarker Studies, and Therapeutics. Front. Neurosci. 14:602235. doi: 10.3389/fnins.2020.602235

Alquezar, C., Felix, J.B., McCandlish, E. et al. Heavy metals contaminating the environment of a progressive supranuclear palsy cluster induce tau accumulation and cell death in cultured neurons. Sci Rep 10, 569 (2020). https://doi.org/10.1038/s41598-019-56930-w

Butler, V. J., Gao, F., Corrales, C. I., Cortopassi, W. A., Caballero, B., Vohra, M., … Kao, A. W. (2019). Age- and stress-associated C. elegans granulins impair lysosomal function and induce a compensatory HLH-30/TFEB transcriptional response. PLoS genetics, 15(8), e1008295. doi:10.1371/journal.pgen.1008295

Butler V.J., Cortopassi W.A., Gururaj S., Wang A.L., Pierce O.M., Jacobson M.P., Kao A.W. (2019). Multi-Granulin Domain Peptides Bind to Pro-Cathepsin D and Stimulate Its Enzymatic Activity More Effectively Than Progranulin in Vitro. Biochemistry, 2019 Jun, 58 (23), 2670-2674 

Butler V.J., Cortopassi W.A., Argouarch A.R., Ivry S.L., Craik C.S., Jacobson M.P., Kao A.W. (2019). Progranulin Stimulates the in vitro Maturation of pro-Cathepsin D at Acidic pH, Journal of Molecular Biology, 2019 Jan, ISSN 0022-2836, https://doi.org/10.1016/j.jmb.2019.01.027.
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Yuan SH, Hiramatsu N, Liu Q, Sun XV, Lenh D, Chan P, Chiang K, Koo EH, Kao AW, Litvan I, Lin JH. Tauopathy-associated PERK alleles are functional hypomorphs that increase neuronal vulnerability to ER stress. Hum Mol Genet. 2018 Nov 15;27(22):3951-3963. doi: 10.1093/hmg/ddy297. PubMed PMID: 30137327; PubMed Central PMCID: PMC6216228.

Butler V.J., Salazar D.A., Soriano-Castell D., Alves-Ferreira M., Dennissen F.J.A., Vohra M., Oses-Prieto J.A., Li K.H., Wang A.L., Jing B., Li B., Groisman A., Gutierrez E., Mooney S., Burlingame A.L., Ashrafi K., Mandelkow E-M., Encalada S.E., Kao A.W. (2018). Tau/MAPT disease-associated variant A152T alters tau function and toxicity via impaired retrograde axonal transport, Human Molecular Genetics, 2018 Dec, ddy442, https://doi.org/10.1093/hmg/ddy442

Hsu TY., Butler V.J., Kao A.W. (2018) The Use of Caenorhabditis elegans to Study Progranulin in the Regulation of Programmed Cell Death and Stress Response. In: Bateman A., Bennett H., Cheung S. (eds) Progranulin. Methods in Molecular Biology, vol 1806. Humana Press, New York, NY

Olney, N.T., Alquezar, C., Ramos, E.M., Nana, A.L., Fong, J.C., Karydas, A.M., Taylor, J.B., Stephens, M.L., Argouarch, A.R., Van Berlo, V.A., Dokuru, D.R., Sherr, E.H., Jicha, G.A., Dillon, W.P., Desikan, R.S., De May, M., Seeley, W.W., Coppola, G., Miller, B.L., Kao, A.W. (2017). Linking tuberous sclerosis complex, excessive mTOR signaling, and age-related neurodegeneration: a new association between TSC1 mutation and frontotemporal dementia. Acta Neuropathologica 2017 Nov;134(5):813-816.

Perry D.C., Brown J.A., Possin K.L., Datta S., Trujillo A., Radke A., Karydas A., Kornak J., Sias A.C., Rabinovici G.D., Gorno-Tempini M.L., Boxer A.L., De May M., Rankin K.P., Sturm V.E., Lee S.E., Matthews B.R., Kao A.W., Vossel K.A., Tartaglia M.C., Miller Z.A., Seo S.W., Sidhu M., Gaus S.E., Nana A.L., Vargas J.N.S., Hwang J.L., Ossenkoppele R., Brown A.B., Huang E.J., Coppola G., Rosen H.J., Geschwind D., Trojanowski J.Q., Grinberg L.T., Kramer J.H., Miller B.L., Seeley W.W. Brain. 2017 Dec 1;140(12):3329-3345

Kao A.W., McKay A., Singh P.P., Brunet A., Huang E.J.. Progranulin, lysosome regulation and neurodegenerative disease. Nature Reviews Neuroscience. 2017 Jun;18(6):325-333.

Bettcher B.M., Fitch R., Wynn M.J., Lalli M.A., Elofson J., Jastrzab L., Mitic L., Miller Z.A., Rabinovici G.D., Miller B.L., Kao A.W.,  Kosik K.S., Kramer J.H. MCP-1 and eotaxin selectively and negatively associate with memory an MCI and Alzheimer's disease dementia phenotypes. Alzheimers Dementia 2016 Jun 22;3:91-7.

Salazar, D.A., V.J. Butler, A.R. Argouarch, T.Y. Hsu, A. Mason, A. Nakamura, H. McCurdy, D. Cox, R. Ng, G. Pan, W.W. Seeley, B.L. Miller, A.W. Kao (2015). The Progranulin Cleavage Products, Granulins, Exacerbate TDP-43 Toxicity and Increase TDP-43 Levels. The Journal of Neuroscience 35(25): 9315–28.

Lalli M.A., Bettcher B.M., Arcila M.L., Garcia G., Guzman C., Madrigal L., Ramirez L., Acosta-Uribe J., Baena A., Wojta K.J., Coppola G., Fitch R., de Both M.D., Huentelman M.J., Reiman E.M., Brunkow M.E., Glusman G., Roach J.C., Kao A.W., Lopera F., Kosik K.S. Whole genome sequencing suggests a chemokine gene cluster that modifies age at onset in familial Alzheimer's disease. Molecular Psychiatry. 2015 Nov;20(11):1294-300.

Judy, M.E., A. Nakamura, A. Huang, H. Grant, H. McCurdy, D.F. Weiberth, F. Gao, G. Coppola, C. Kenyon,  A.W. Kao (2013). A shift to organismal stress resistance in programmed cell death mutants. PLoS Genet 9(9): e1003714.

​Kao, A.W., R.J. Eisenhut, L.H. Martens, A. Nakamura, J.A. Bagley, A. Huang, A. de Luis, L.J. Neukomm, J. Cabello, R.V. Farese, Jr., C.J. Kenyon (2011). A neurodegenerative disease mutation that accelerates the clearance of apoptotic cells. PNAS 108:4441-6.

Kao, A.W., C. Racine, L. Quitania, J. Kramer, C. Christine and B.L. Miller (2009). Cognitive and neuropsychiatric profiles of the “Synucleinopathies”: Comparison of Parkinson’s Disease, Dementia with Lewy Bodies and Multiple System Atrophy.  Alzheimer Dis. And Assoc. Disord. 23: 365-70.

Kao, A. W. and J. E. Pessin (2000). Functional comparison of four dynamin 2 splice variants on GLUT4 endocytosis in 3T3L1 adipocytes. Am. J. Physiol. Endocrinol. Metab. 278: E825-31.

Duan, D. S., Q. Li, A. W. Kao, Y. Yue, J. E. Pessin, and J. F. Engelhardt (1999) Dynamin is required for Recombinant Adeno-associated Virus-2 Infection. J. Virology 73: 10371-6.

Summers, S. A., A. W. Kao, A. D. Kohn, G. S. Backus, R. A. Roth, J. E. Pessin and M. J. Birnbaum (1999). The role of Glycogen Synthase Kinase 3ß in insulin-simulated glucose metabolism. J. Biol. Chem. 274:17934-17940.

Kao, A. W., Y. Noda, J. H. Johnson, J. E. Pessin and A. R. Saltiel (1999). Aldolase mediates the association of F-actin with the insulin regulatable glucose transporter GLUT4. J. Biol. Chem.  274: 17742-17747.

Ceresa, B., A. W. Kao, S. Santeler and J. E. Pessin (1998). Regulation of insulin signaling pathways by clathrin-mediated endocytosis. Mol. Cell. Biol. 18: 3862-3870.

Kao, A. W., B. Ceresa, S. Santeler and J. E. Pessin (1998). Expression of a dominant interfering dynamin mutant in 3T3L1 adipocytes inhibits GLUT4 endocytosis without affecting insulin signaling. J. Biol. Chem. 273:25450-25457.

Okada, S., A. W. Kao, B. Ceresa, P. Blaikie, B. Margolis, J. E. Pessin (1997). The 66 kDa Shc isoform is a negative regulator of the Epidermal Growth Factor-simulated Mitogen-Activated Protein Kinase pathway. J. Biol. Chem. 272: 28179.

Waters, S. W., D. Chen, A. W. Kao, K. H. Holt., and J. E. Pessin (1996). Insulin and Epidermal Growth Factor utilize distinct pools of Grb2-SOS in the regulation of Ras activation. J. Biol. Chem. 27: 18224-18230.

Kao, A. W., S. B. Waters, S. Okada and J. E. Pessin (1996). Insulin and osmotic shock stimulate the serine phosphorylation of the 66 kDA Shc isoform through a MEK-dependent pathway. Endocrinology 138: 2474-2480.

Bearer, E. L., J. A. DeGiorgis, R. A. Bodner, A. W. Kao and T. S. Reese (1993). Evidence for myosin motors on organelles in squid axoplasm. Proc. Natl. Acad. Sci. 90: 11252-11256.

Press

Astonishing Animals that Illuminate Human Health- https://www.ucsf.edu/magazine/astonishing-animals